Biosynthesis of cephalosporin C.
نویسندگان
چکیده
The superiority of d-methionine over l-methionine for stimulation of cephalosporin C synthesis in a crude medium was confirmed. The optimal level of dl-methionine was 0.5%. Methionine stimulates growth slightly but this is not thought to be the cause of the marked stimulation of antibiotic synthesis. Of a large number of sulfur compounds tested, only dl-methionine-dl-sulfoxide and S-methyl-l-cysteine showed considerable methionine-replacing activity. Lysine and alpha-aminoadipic acid were inactive.
منابع مشابه
Regulation of cephalosporin biosynthesis.
The filamentous fungus Acremonium chrysogenum is the natural producer of the beta-lactam antibiotic cephalosporin C and is as such used worldwide in major biotechnical applications. Albeit its profound industrial importance, there is still a limited understanding about the molecular mechanisms regulating cephalosporin biosynthesis in this fungus. This review focuses on various regulatory levels...
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عنوان ژورنال:
- Applied microbiology
دوره 10 شماره
صفحات -
تاریخ انتشار 1962